The promising potential role of ketones in inflammatory dermatologic disease: a new frontier in treatment research

This literature review correlates known mechanisms of inflammation in dermatologic disease with suggested anti-inflammatory mechanisms of ketones and ketosis. It reports that ketones modulate the NRPL3 inflammasome, augment anti-oxidation against reactive oxygen species through direct and indirect means, and may influence mTOR activity, all of which are involved in inflammatory skin disease to an extent. The authors state a goal of providing a new direction for research on the ketogenic diet and exogenous ketone therapy in inflammatory dermatologic disease.