The Growth Response to Beta-Hydroxybutyrate in SH-SY5Y Neuroblastoma Cells is Suppressed by Glucose and Pyruvate Supplementation

This in vitro study tested how beta-hydroxybutyrate affects the growth of SH-SY5Y neuroblastoma cells in the presence or absence of glucose and pyruvate. Glucose deprivation reduced growth and viability, and the cells were initially unaffected by added beta-hydroxybutyrate. A growth response to beta-hydroxybutyrate later appeared in low-glucose media and in glucose- and pyruvate-deprived conditions.