The Evolution of Ketosis: Potential Impact on Clinical Conditions

This perspective reviews the signaling and energetic roles of ketone bodies, including their links to nutrition and metabolic pathways and the potential impact on clinical conditions. The authors searched Medline/PubMed, Scopus, Web of Sciences and the Cochrane Library until July 2022. They state that the literature data need confirmation in consistent clinical trials because much comes from in vitro and animal models. They add that data on exogenous ketone consumption and brain uptake and metabolism might spur research into acute and chronic effects of ketone bodies in humans.