This is a protocol for a randomized, placebo-controlled, double-blind crossover trial in 34 middle-to-older adults (50 percent female, aged 55 to 75) with subjective cognitive decline. Each participant will take a ketone monoester or placebo three times daily for 14 days, then repeat the protocol with the other intervention after a washout of at least 14 days. Outcomes are cerebral blood flow, functional brain connectivity and cerebrovascular function by MRI, cognitive performance on psychometric tests, and blood neurotrophic factors.
A goBHB specialist picks these up and answers inside one business day.