The effect of a ketone monoester drink on blood glucose and substrate oxidation in adults with metabolic syndrome and matched controls

This randomized, single-blind, placebo-controlled crossover study compared 8 adults with metabolic syndrome (MetS) and 8 matched adults without it. Respiratory gases were measured at baseline and at 45 and 105 minutes after a ketone ester (KE) or placebo beverage. After KE, respiratory exchange ratio, carbohydrate oxidation and blood ketones increased significantly, while blood glucose and fat oxidation decreased, irrespective of group. The MetS group had higher beta-hydroxybutyrate responses to KE than controls, and resting energy expenditure was not altered.