Targeting Ketone Body Metabolism Improves Cardiac Function and Hemodynamics in Patients With Heart Failure: A Systematic Review and Meta-Analysis

Lv T et al.

Nutrition reviews

Key finding

Across seven human studies, ketone therapy significantly improved left ventricular ejection fraction (standardized mean difference 0.52) and cardiac output (0.84) and reduced systemic vascular resistance (-0.92) in patients with heart failure.

What the study did

This systematic review and meta-analysis searched PubMed, Cochrane Library, and Embase through April 13, 2024, and included seven human studies of ketone therapy (ketone ester and beta-hydroxybutyrate) in heart failure. Ketone therapy significantly improved left ventricular ejection fraction (standardized mean difference 0.52, 95 percent CI 0.25 to 0.80), cardiac output (0.84), and stroke volume (0.47), and reduced systemic vascular resistance (-0.92) without changing mean arterial pressure (-0.09). Subgroup analysis found the effects also applied to individuals without heart failure.

This study used [form], not goBHB. It is shown here as general ketone science. Only goBHB studies back goBHB product claims.

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