Putative Role of Adenosine A1 Receptors in Exogenous Ketone Supplements-Evoked Anti-Epileptic Effect

This literature review focuses on the proposed role of adenosine A1 receptors in the anti-epileptic effect of exogenous ketone supplement-induced ketosis. It notes that therapeutic ketosis may decrease epileptic activity in animal models and humans, that ketosis can increase adenosine levels, and that adenosine has an anti-epileptic effect through A1 receptors in different epilepsy models. The abstract frames the role of A1 receptors as a possibility and a putative mechanism, and reports no new experimental results.