Prior ingestion of a ketone monoester supplement reduces postprandial glycemic responses in young healthy-weight individuals

Nineteen healthy young volunteers (10 males, 9 females) took part in a double-blind, placebo-controlled crossover study. After an overnight fast they consumed 0.45 mL/kg of a ketone monoester or a taste-matched placebo, followed 15 minutes later by a mixed-meal tolerance test. The ketone monoester raised beta-hydroxybutyrate area under the curve by 590 percent and lowered blood glucose area under the curve by 9.4 percent and nonesterified fatty acid area under the curve by 27.3 percent versus placebo. Insulin area under the curve and gastric emptying estimates did not differ between conditions.