Modulation of beta-hydroxybutyrate in traumatic brain injury

This review covers the metabolism of beta-hydroxybutyrate (BHB), its effects in traumatic brain injury (TBI) and its potential therapeutic role. It describes BHB as producible by fasting or given through ketogenic diets and oral or intravenous supplements, and lists proposed benefits in TBI including reduced oxidative stress and inflammation, control of excitotoxicity, promotion of mitochondrial respiration and support of brain regeneration. The authors state that timing, dosage and long-term effects of ketone use in TBI patients require further investigation.