Metabolic markers of short and long-term exogenous DL-beta-hydroxybutyrate supplementation in episodic migraine patients

Exploratory analysis of the randomized crossover migraine trial in 41 patients using an oral DL-Mg-Ca-beta-hydroxybutyrate salt. A single 6 g dose raised blood ketones to about 0.46 mM at 40 minutes and lowered glucose from 4.91 to 4.75 mM. Twelve weeks at 18 g per day did not change acute ketone response or HbA1c.