Ketone-targeting Approaches in Glioma

This review summarizes preclinical and clinical data on ketogenic metabolic therapies in gliomas, including fasting, ketogenic diet therapy, exogenous ketone supplementation, or a combination. It reports that preclinical evidence suggests these approaches can impair tumor growth, normalize the tumor microenvironment, and enhance sensitivity to cancer-directed therapies. Clinical studies highlight their safety as well as challenges related to tolerability and biological effect.