Ketone metabolites in metabolic dysfunction-associated steatotic liver disease progression: optimizing keto-therapeutic strategies

This review examines ketone metabolism in metabolic dysfunction-associated steatotic liver disease (MASLD). It states that impaired ketogenesis is observed in MASLD and that ketogenic interventions, including exogenous ketone supplementation and ketogenic diets, have been shown to be hepatoprotective, attenuating steatosis, inflammation, and fibrosis. It also discusses ketogenic enzyme loss- and gain-of-function studies and gaps in the current literature.