Ketone Ester Supplementation Improves Some Aspects of Cognitive Function during a Simulated Soccer Match after Induced Mental Fatigue

In a double-blind, balanced crossover study, nine recreationally active men completed a 45 minute simulated soccer match after a 40 minute mental fatiguing task, consuming either a ketone monoester (25 g) or a non-caloric placebo. Cognitive function (Stroop and Choice Reaction Task, CRT) and blood metabolites were measured throughout. The monoester lowered blood glucose (block 2: 4.6 versus 5.2 mM; block 3: 4.7 versus 5.3 mM) and blood lactate (block 2: 4.9 versus 5.9 mM). No other differences in cognitive function were seen.