Ketone Ester Attenuates Thoracic Aortic Aneurysm and Dissection by Suppressing Ferroptosis

Researchers induced thoracic aortic aneurysm and dissection (TAAD) in C57BL/6 mice with beta-aminopropionitrile and gave some of them a ketone ester at 20 g/L in drinking water starting on day 15 of treatment. Ketone ester reduced TAAD incidence from 69 percent to 43 percent, improved survival from 52 percent to 73 percent, preserved aortic structure and reduced elastic fiber fragmentation. In human aortic smooth muscle cells, beta-hydroxybutyrate inhibited ferroptosis caused by GPX4 inhibition, and in mice the ketone ester restored GPX4 and SLC7A11 expression while suppressing HO-1.