Impact of the Combination of Epigallocatechin Gallate and Ellagic Acid Supplemented with Ketone Bodies on Energetic Restoration of Mitochondrial Dysfunction and Metabolic Inefficiencies in Patients with Multiple Sclerosis: A Review

This review examines combining beta-hydroxybutyrate (BHB), epigallocatechin-3-gallate (EGCG), and ellagic acid as a multi-target strategy to restore mitochondrial function in multiple sclerosis (MS), which involves dysfunction of electron transport chain complexes I, III, and IV. It describes complementary mechanisms for each compound and reports that clinical trials have shown improvements in fatigue, cognition, mood, and muscle function with these compounds. It also names exogenous ketone salts, liposomal EGCG, and microencapsulated ellagic acid as delivery strategies that may overcome bioavailability limits.