From bedside to battlefield: intersection of ketone body mechanisms in geroscience with military resilience

This review summarizes the biology of ketone bodies relevant to resilience and rehabilitation in military service members. It describes ketone bodies as supplying energy to tissues such as brain, heart and skeletal muscle and as having protein-binding activities that regulate inflammation, epigenetics and other cellular processes. It discusses their possible relevance to stressors that mimic or accelerate aging pathways, particularly traumatic brain injury and muscle rehabilitation and recovery, along with strategies for translational use and current clinical investigations.