Exploratory functional and quality of life outcomes with daily consumption of the ketone ester bis-octanoyl (R)-1,3-butanediol in healthy older adults: a randomized, parallel arm, double-blind, placebo-controlled study

This was a 12-week randomized, double-blind, placebo-controlled, parallel-arm pilot trial in community-dwelling adults aged 65 and older, in which 30 participants were randomized 1:1 to 25 g daily of the ketone ester bis-octanoyl (R)-1,3-butanediol or a calorie-matched canola oil placebo. Exploratory physical function, cognitive function, quality of life and wearable-measured activity outcomes were assessed in 23 completers (11 placebo, 12 ketone ester).