Effects of ketone supplementation on metabolic and hormonal profiles in polycystic ovary syndrome: A systematic review and meta-analysis

Khan SA et al.

Medicine

Key finding

Pooled analysis found that ketone supplementation in women with PCOS was associated with significant reductions in BMI, glucose, insulin, LH and androgens, and significant increases in FSH and estrogen, while the cholesterol change was not significant.

What the study did

This systematic review and meta-analysis pooled clinical studies of ketone supplementation in women with PCOS using inverse-variance random-effects models. Ketone supplementation was associated with a significant reduction in BMI (IV -13.08; 95 percent CI -17.47 to -8.69; I2 = 0 percent), serum glucose (IV -10.83; I2 = 93 percent) and insulin (IV -11.87; I2 = 93 percent). The reduction in cholesterol was not statistically significant (P = 0.19), LH and androgen levels fell significantly, and FSH and estrogen levels rose significantly.

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