Effects of Hypocaloric Low-Fat Ketogenic and Ketogenic and Ketone Supplement Diets on Aldosterone and Renin

Randomized trial in 28 adults on a hypocaloric ketogenic diet with ketone salts or placebo, plus a 12-person low-fat arm. After 6 weeks aldosterone rose 88 percent with placebo and 144 percent with ketone salts, with no change on the low-fat diet. Cardiometabolic risk factors did not worsen.