Effect of acute ketosis on lipid profile in prediabetes: findings from a cross-over randomized controlled trial

In a randomized crossover trial, 18 adults with prediabetes (6 women, 12 men) ingested a single dose of a ketone monoester beta-hydroxybutyrate drink or a placebo drink after an overnight fast, with blood sampled every 30 minutes up to 150 minutes. Blood beta-hydroxybutyrate rose from 0.2 mmol/L to 3.5 mmol/L (p < 0.001) within 30 minutes. Areas under the curve for total cholesterol, HDL cholesterol, LDL cholesterol and the triglyceride to HDL ratio did not differ significantly, and the changes in remnant cholesterol and triglycerides were significant in people with high but not low habitual saturated fat intake.