This early feasibility study (GLOW) implanted a near-infrared spectroscopy sensor for 28 days in 7 participants, 4 with type 1 diabetes and 3 healthy volunteers. Metabolic challenges varied glucose and raised ketones (ketone drink, up to 3.5 mM), lactate (up to 13 mM) and ethanol, and sensor readings were compared with reference blood and breath measurements. The sensor was safe and well tolerated with no infectious or wound healing complications, and 6 of 7 sensors stayed fully operational for the whole period.
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