Disparate Hepatic Mitochondrial and Inflammatory Effects of Ketone Supplements

Morris TJ, Morris MD, Parker AJ, Heggie JR, Roeth EJ, et al.; senior author Bikman BT

Nutrients

Key finding

D-BHB and L-BHB raised liver ATP while 1,3-butanediol depleted ATP and drove liver inflammation and fat in mice.

What the study did

Mice received D-BHB, L-BHB, or 1,3-butanediol by gavage, once or daily for 8 days. Both BHB forms raised liver ATP while 1,3-butanediol depleted it. After 8 days butanediol lowered mitochondrial complex II respiration and raised IL-1beta, TNF-alpha, CRP, and liver triglycerides. BHB groups stayed at control levels. The BHB material came from Ketone Labs.

This study used [form], not goBHB. It is shown here as general ketone science. Only goBHB studies back goBHB product claims.

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