β-Hydroxybutyrate Enhances the Metabolic Fitness of CAR T Cells in Cancer

Preclinical study across multiple cancer models testing BHB alongside CAR T cell therapy. BHB raised CAR T oxidative phosphorylation and ATP production, boosting proliferation, cytokine output, and tumor control. In healthy human volunteers, BHB intake raised T cell oxygen consumption, mitochondrial membrane potential, and ATP production.