Ketone ester/other
Human RCT
2026
Acute exogenous ketone monoester supplementation decreases indices of cardiac vagal modulation in a dose-dependent manner in healthy adults
Thiessen J et al.
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Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
Key finding
Ketone monoester at 0.3 and 0.6 g/kg lowered the heart rate variability measures pRR50 and RMSSD at 45 and 120 minutes after ingestion compared with placebo in 18 healthy adults.
What the study did
This randomized, double-blind crossover study analyzed heart rate variability in 18 healthy adults (average age 23, 10 of them female) who ingested 0.3 or 0.6 g/kg ketone monoester or placebo. Both doses raised plasma beta-hydroxybutyrate compared with placebo. Both doses also reduced pRR50 and RMSSD, two measures of heart rate variability, at 45 minutes (both p < 0.02) and at 120 minutes after ingestion (both p < 0.01).
This study used [form], not goBHB. It is shown here as general ketone science. Only goBHB studies back goBHB product claims.