A Randomized Open-Label, Observational Study of the Novel Ketone Ester, Bis Octanoyl (R)-1,3-Butanediol, and Its Acute Effect on ß-Hydroxybutyrate and Glucose Concentrations in Healthy Older Adults

This randomized, open-label, observational study in 30 healthy older adults (50 percent male, average age 76.5 years) tested 12.5 or 25 g of the ketone ester bis-octanoyl (R)-1,3-butanediol (BO-BD) in a ready-to-drink beverage (n = 30) and a reconstituted powder (n = 21) taken with a meal. All interventions were well tolerated and raised blood beta-hydroxybutyrate, producing nutritional ketosis (0.5 mM or higher) until the end of the 4-hour study. Peak concentration and incremental area under the curve were significantly greater with 25 g than 12.5 g in both formulations, with no significant differences between formulations.