A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease

This case report describes prolonged oral administration of ketone monoester to one patient with Alzheimer's disease dementia who had a pretreatment Mini-Mental State Examination score of 12. The treatment lasted 20 months and the ketone monoester was well tolerated throughout. The patient improved markedly in mood, affect, self-care, and cognitive and daily activity performance. Cognitive performance tracked plasma beta-hydroxybutyrate concentrations, with noticeable improvements in conversation and interaction at the higher levels compared with predose levels.