Fifteen normal-weight subjects consumed, after an overnight fast, 1.9 kcal/kg of ketone ester or isocaloric dextrose in drinks matched for volume, taste, tonicity and color. Ketone ester raised blood BHB from 0.2 to 3.3 mM after 60 minutes. Postprandial plasma insulin, ghrelin, GLP-1 and PYY were significantly lower 2 to 4 hours after ketone ester than after dextrose.
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