14-Day Ketone Supplementation Lowers Glucose and Improves Vascular Function in Obesity: A Randomized Crossover Trial

In this randomized crossover trial, 14 adults with obesity consumed a ketone monoester drink (12 g beta-hydroxybutyrate) or placebo 15 minutes before each meal for 14 days, with meals provided and matched. Postprandial glucose was 8.0 percent lower with the ketone monoester (p = 0.011) and 24-hour average glucose was 7.8 percent lower (p = 0.0001). Brachial artery flow-mediated dilation rose from 6.2 percent to 8.9 percent with the ketone monoester and did not change with placebo, and monocyte caspase-1 activation was lower, while plasma cytokines did not change.